Dimethylcarbamoyl Chloride → alpha-Diethylcarbamylthio-6-methoxy-2-naphthylacetic acid

HRID 1579843

반응식

HRID 1579843 반응식
[CH2:1]([N:3]([CH2:7][CH3:8])[C:4](Cl)=[O:5])[CH3:2].C(Cl)(=O)N.C(NC(Cl)=O)C.CN(C)C(Cl)=O.C([S:28][CH:29]([C:33]1[CH:42]=[CH:41][C:40]2[C:35](=[CH:36][CH:37]=[C:38]([O:43][CH3:44])[CH:39]=2)[CH:34]=1)[C:30]([OH:32])=[O:31])(=O)N.C(NC(SC(C1C=CC2C(=CC=C(OC)C=2)C=1)C(O)=O)=O)C.CN(C)C(SC(C1C=CC2C(=CC=C(OC)C=2)C=1)C(O)=O)=O>>[CH2:1]([N:3]([CH2:7][CH3:8])[C:4]([S:28][CH:29]([C:33]1[CH:42]=[CH:41][C:40]2[C:35](=[CH:36][CH:37]=[C:38]([O:43][CH3:44])[CH:39]=2)[CH:34]=1)[C:30]([OH:32])=[O:31])=[O:5])[CH3:2]

참가 물질

8

반응물 7

HCID 6598Dimethylcarbamoyl ChlorideHCID 6916Diethylcarbamoyl chlorideHCID 68048Carbamic chlorideHCID 12321963N-ethylcarbamoyl chlorideHCID 21569102alpha-Carbamylthio-6-methoxy-2-naphthylacetic acidHCID 21569125alpha-Dimethylcarbamylthio-6-methoxy-2-naphthylacetic acidHCID 86732901alpha-Ethylcarbamylthio-6-methoxy-2-naphthylacetic acid

생성물 1

HCID 21569122alpha-Diethylcarbamylthio-6-methoxy-2-naphthylacetic acid

실험 절차

When diethylcarbamylchloride is replaced in the above procedure by carbamyl chloride (prepared in situ from potassium cyanate and anhydrous hydrogen chloride in anhydrous chloroform), ethylcarbamyl chloride or dimethylcarbamyl chloride, then the products prepared are α-carbamylthio-6-methoxy-2-naphthylacetic acid, α-ethylcarbamylthio-6-methoxy-2-naphthylacetic acid or α-dimethylcarbamylthio-6-methoxy-2-naphthylacetic acid.

후처리

  1. customthe products prepared

출처 및 근거

ORD 기록
ord-223595e68bfe40c3bf6bc68e0ad04983
출처 데이터셋
uspto-grants-1976_01
특허 번호
US03931269

연결된 노트

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