5-Aminosalicylic Acid → HCID 12270313, 화합물

HRID 1579906노트

반응식

HRID 1579906 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]([CH2:12][C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=O)[C:7](=O)[CH2:6][CH2:5]2.[NH2:22][C:23]1[CH:31]=[C:27]([C:28]([OH:30])=[O:29])[C:26]([OH:32])=[CH:25][CH:24]=1.CC(OCC1C2C(=CC=CC=2)C(COC(C)=O)=C2C=1C=CC=C2)=O>>[C:28]([C:27]1[CH:31]=[C:23]([N:22]2[C:7]3[CH2:6][CH2:5][C:4]4[CH:3]=[C:2]([Cl:1])[CH:11]=[CH:10][C:9]=4[C:8]=3[CH:12]=[C:13]2[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:24]=[CH:25][C:26]=1[OH:32])([OH:30])=[O:29]

참가 물질

4

반응물 3

HCID 40755-Aminosalicylic AcidHCID 613145Acetic acid 10-acetoxymethyl-anthracen-9-ylmethyl esterHCID 122703422(1H)-Naphthalenone, 6-chloro-3,4-dihydro-1-(2-oxo-2-phenylethyl)-

생성물 1

HCID 12270313HCID 12270313, 화합물

실험 절차

A mixture of 10.1 g. (0.03 mole) of 6-chloro-1-phenacyl-2-tetralone, 4.5 g. (0.03 mole) of 5-aminosalicylic acid and 30 ml. of glacial acetic was heated under reflux for 70 minutes, cooled and filtered. The collected solid was washed with acetic acid and petroleum ether and recrystallized from acetonitrile to give 4.3 g. (59%) of colorless crystals, m.p. 249°-251°.

후처리

  1. additionA mixture of 10.1 g
  2. temperatureunder reflux for 70 minutes
  3. temperaturecooled
  4. filtrationfiltered
  5. washThe collected solid was washed with acetic acid and petroleum ether
  6. customrecrystallized from acetonitrile
  7. customto give 4.3 g

출처 및 근거

ORD 기록
ord-520cfdc009d849d29f7d7af0ad47a115
출처 데이터셋
uspto-grants-1976_01
특허 번호
US03931407

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