Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → N-(5-Hydroxy-6-sulfamoylnaphthalen-1-yl)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Chloroform | HCID 6212 | — |
| 반응물 | 2-Naphthalenesulfonyl chloride, 5-(acetylamino)-1-(acetyloxy)- | HCID 94125 | — |
| 반응물 | Ammonium Carbonate | HCID 517111 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N-(5-Hydroxy-6-sulfamoylnaphthalen-1-yl)acetamide | HCID 21486282 | — |
반응 단계
The 5-acetamido-1-hydroxynaphthalene-2-sulfonamide was prepared by dissolving 10.8 g. of 5-acetamido-1-acetoxynaphthalene-2-sulfonyl chloride in 10 ml. dry chloroform and heating on the steam bath with 25.0 g. anhydrous ammonium carbonate for 2.5 hours. The yellow-brown solid was dissolved by heating with 50 ml. water on the steam bath for 4 hours. Acidification with dilute hydrochloric acid to pH5 caused the sulfonamide to precipitate. It was filtered off, washed and dried, yielding 5.61 g. (63%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03932380 |
| 출처 데이터셋 | uspto-grants-1976_01 |
| ORD ID | ord-61010f5867524eb4bbd5b94f8f727856 |
| 출처 메모 | uspto-grants-1976_01 |