Benzene → Ethyl 5-methyl-2-phenylimidazole-4-acetate

HRID 1580096노트

반응식

HRID 1580096 반응식
[CH3:1][C:2]1[NH:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][C:14]([OH:16])=[O:15].[CH2:17](O)[CH3:18].C1(C)C=CC(S(O)(=O)=O)=CC=1.C1C=CC=CC=1>O>[CH3:1][C:2]1[NH:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]

참가 물질

6

반응물 4

HCID 241BenzeneHCID 702EthanolHCID 6101p-Toluenesulfonic acidHCID 215650655-Methyl-2-phenylimidazole-4-acetic acid

생성물 1

HCID 22597552Ethyl 5-methyl-2-phenylimidazole-4-acetate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

About 40 g of 5-methyl-2-phenylimidazole-4-acetic acid, 100 ml of absolute ethanol, 1 g of p-toluenesulfonic acid and 650 ml of benzene is heated under reflux with azeotropic removal of water overnight (about 15 hours). The reaction mixture is filtered, washed with sodium bicarbonate solution, dried over anhydrous magnesium sulfate and the solvent evaporated in vacuo to yield the product, ethyl 5-methyl-2-phenylimidazole-4-acetate.

후처리

  1. filtrationThe reaction mixture is filtered
  2. washwashed with sodium bicarbonate solution
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customthe solvent evaporated in vacuo

출처 및 근거

ORD 기록
ord-704dcf766cc24e3e82f991e7e055e8d0
출처 데이터셋
uspto-grants-1976_01
특허 번호
US03932445

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