Sodium Methoxide → HCID 18594804, 화합물

HRID 1580235노트

반응식

HRID 1580235 반응식
C([S:4][CH:5]([CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH2:6][CH2:7][C@@H:8]1[C@@H:12]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:11](=[O:24])[CH2:10][CH2:9]1)(=O)C.C[O-].[Na+]>CO>[O:24]=[C:11]1[CH2:10][CH2:9][C@H:8]([CH2:7][CH2:6][CH:5]([SH:4])[CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[C@H:12]1[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20]

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 18594874HCID 18594874, 화합물

생성물 1

HCID 18594804HCID 18594804, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 606 mg. of ethyl 15-acetylthio-9-oxoprostanoate (Example 113) in 20 ml. of reagent methanol is treated, under nitrogen atmosphere, with 1.6 ml. of 1N methanolic sodium methoxide. After 10 minutes the reaction is quenched by the addition of 0.3 ml. of glacial acetic acid and taken to dryness. A solution of the residue in ether is washed with saturated sodium chloride solution, dried with anhydrous magnesium sulfate and taken to dryness to afford 428 mg. (89%) of an oil; λmax. 4.0 (sulfhydryl) and 5.78 μ (carbonyls).

후처리

  1. customAfter 10 minutes the reaction is quenched by the addition of 0.3 ml
  2. washA solution of the residue in ether is washed with saturated sodium chloride solution
  3. dry with materialdried with anhydrous magnesium sulfate
  4. customto afford 428 mg

출처 및 근거

ORD 기록
ord-9b63541ab430480fb40b028b798140fe
출처 데이터셋
uspto-grants-1976_01
특허 번호
US03932472

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