O-Xylene → 2H-1,5-Benzodiazepine-2-thione, 1,3-dihydro-4-phenyl-
반응식
[C:1]1([NH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH2:7].C1(C)C(C)=CC=CC=1.[C:17]([CH2:25][C:26](S)=[S:27])(=O)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.O1CCOCC1>O>[C:18]1([C:17]2[CH2:25][C:26](=[S:27])[NH:8][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=3[N:7]=2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1참가 물질
6
실험 절차
A mixture of 1.08 g of o-phenylendiamine, 10 ml of xylene and 1.96 g of benzoyldithioacetic acid (Thuillier et al - Bull. Soc. Chim. Fr. 1938 (1959) is refluxed for 1 hour under a stream of nitrogen. The reaction may also be carried out in water, alcohol or dioxane. After cooling, the precipitate is filtered, washed with ethyl ether, and crystallized from ethyl acetate. Yield 2 g, m.p. 228°-230°C.
후처리
- temperature1938 (1959) is refluxed for 1 hour under a stream of nitrogen
- customThe reaction
- temperatureAfter cooling
- filtrationthe precipitate is filtered
- washwashed with ethyl ether
- customcrystallized from ethyl acetate
출처 및 근거
- ORD 기록
- ord-578e21f2f5b84458b25b5a8d1fbdf87a
- 출처 데이터셋
- uspto-grants-1976_01
- 특허 번호
- US03933793
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