2-Propenoyl chloride, 3-(3,4,5-trimethoxyphenyl)-, (2E)- → 5,6,13,13a-tetrahydro-2,3,11-trimethoxy-10-(3', 4', 5'-trimethoxycinnamoyloxy)-8H-dibenzo[a, g]quinolizine

HRID 1580598

반응식

HRID 1580598 반응식
Cl.[OH:2][C:3]1[C:4]([O:25][CH3:26])=[CH:5][C:6]2[CH2:15][CH:14]3[N:9]([CH2:10][CH2:11][C:12]4[CH:19]=[C:18]([O:20][CH3:21])[C:17]([O:22][CH3:23])=[CH:16][C:13]=43)[CH2:8][C:7]=2[CH:24]=1.[CH3:27][O:28][C:29]1[CH:30]=[C:31]([CH:37]=[C:38]([O:42][CH3:43])[C:39]=1[O:40][CH3:41])[CH:32]=[CH:33][C:34](Cl)=[O:35]>N1C=CC=CC=1>[CH3:23][O:22][C:17]1[C:18]([O:20][CH3:21])=[CH:19][C:12]2[CH2:11][CH2:10][N:9]3[CH:14]([CH2:15][C:6]4[CH:5]=[C:4]([O:25][CH3:26])[C:3]([O:2][C:34](=[O:35])[CH:33]=[CH:32][C:31]5[CH:30]=[C:29]([O:28][CH3:27])[C:39]([O:40][CH3:41])=[C:38]([O:42][CH3:43])[CH:37]=5)=[CH:24][C:7]=4[CH2:8]3)[C:13]=2[CH:16]=1

참가 물질

4

반응물 2

HCID 1120942-Propenoyl chloride, 3-(3,4,5-trimethoxyphenyl)-, (2E)-HCID 8673298310-hydroxy-2,3,11-trimethoxy-5,6,13,13a-tetrahydro-8H-dibenzo[a, g]quinolizine hydrochloride

생성물 1

HCID 867329855,6,13,13a-tetrahydro-2,3,11-trimethoxy-10-(3', 4', 5'-trimethoxycinnamoyloxy)-8H-dibenzo[a, g]quinolizine수율 46.4%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

1.9 g of 10-hydroxy-2,3,11-trimethoxy-5,6,13,13a-tetrahydro-8H-dibenzo[a, g]quinolizine hydrochloride was treated in the same manner as described in Example 6, using 2.0 g of 3,4,5-trimethoxycinnamoyl chloride and 20 ml of anhydrous pyridine and there was obtained 1.3 g (46.4% yield) of 5,6,13,13a-tetrahydro-2,3,11-trimethoxy-10-(3', 4', 5'-trimethoxycinnamoyloxy)-8H-dibenzo[a, g]quinolizine as a pale yellow powder. The methiodide derived from this compound was found to be in agreement with the methiodide of the compound obtained in Example 5 as determined from the melting point and IR spectrum.

출처 및 근거

ORD 기록
ord-47292063710140caa1214a1d5fff1ce6
출처 데이터셋
uspto-grants-1976_01
특허 번호
US03933826

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