3-Amino-1-propanol → 1-(2,4-Dimethylphenyl)-3-(3-hydroxypropyl)thiourea

HRID 1580631

반응식

HRID 1580631 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]=[C:10]=[S:11].[OH:12][CH2:13][CH2:14][CH2:15][NH2:16]>C1C=CC=CC=1>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]([NH:16][CH2:15][CH2:14][CH2:13][OH:12])=[S:11]

참가 물질

4

반응물 2

HCID 90863-Amino-1-propanolHCID 1423861-Isothiocyanato-2,4-dimethylbenzene

생성물 1

HCID 21711911-(2,4-Dimethylphenyl)-3-(3-hydroxypropyl)thiourea

시약·촉매·용매 1

HCID 241Benzene용매2회

실험 절차

A solution of 2,4-dimethylphenylisothiocyanate in about 70 ml. of benzene was added dropwise to an agitated solution of 3-hydroxypropylamine (3.8 grams) in about 80 ml. of benzene. The resulting reaction mixture was maintained, with stirring, at ambient temperatures for about 16 hours. Following such period, the benzene in the reaction mixture was removed in vacuo and the residual oil triturated with ethyl ether and the desired product crystallized therefrom and washed again with ethyl ether. As a result of such operations, the desired N-(2,4-dimethylphenyl)-N'-(3-hydroxypropyl)-thiourea product was obtained as a white solid having a melting point of 90° - 93°C.

후처리

  1. customThe resulting reaction mixture
  2. temperaturewas maintained
  3. waitFollowing such period
  4. customthe benzene in the reaction mixture was removed in vacuo
  5. customthe residual oil triturated with ethyl ether
  6. customthe desired product crystallized
  7. washwashed again with ethyl ether
  8. customAs a result of such operations

출처 및 근거

ORD 기록
ord-94561180df864c719153891f18af9760
출처 데이터셋
uspto-grants-1976_01
특허 번호
US03933833

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