Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thiocyanic Acid → 4,5-Diphenyl-2-oxazolyl mercaptoacetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thiocyanic Acid | HCID 781 | — |
| 반응물 | Bromoacetic Acid | HCID 6227 | — |
| 반응물 | Benzoin | HCID 8400 | — |
| 반응물 | Phosphorus sulfide (P2S5) | HCID 14817 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 4,5-Diphenyl-4-oxazolin-2-one | HCID 151245 | — |
| 반응물 | HCID 178527826 | HCID 178527826 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | 4,5-Diphenyl-2-oxazolyl mercaptoacetic acid | HCID 21408360 | — |
반응 단계
12 g. of 2-mercapto-4,5-diphenyl-oxazole (m.p. 252°-254°, from methanol; obtainable from 4,5-diphenyl-2-oxazolone and phosphorus pentasulfide in boiling xylene, or by the reaction of benzoin with HSCN) is dissolved in 100 ml. of DMF, and 1.2 g. of NaH is added thereto. The reaction mixture is agitated for 1.5 hours at room temperature. Then, 5.6 ml. of the ethyl ester of bromoacetic acid in 20 ml. of DMF is added dropwise thereto, and the reaction mixture is stirred for 2 hours at 80°. The mixture is then mixed with water and worked up as usual, thus obtaining the ethyl ester of 4,5-diphenyl-2-oxazolyl-mercaptoacetic acid, b.p. 207°-210°/0.1 mm.; m.p. 54°-56° (hexane).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03933840 |
| 출처 데이터셋 | uspto-grants-1976_01 |
| ORD ID | ord-48d6f71e58f743a39566282b6eeb664d |
| 출처 메모 | uspto-grants-1976_01 |