Z-Thr(tbu)-ome → (2S,3R)-Methyl 2-amino-3-(tert-butoxy)butanoate

HRID 1580865노트

반응식

HRID 1580865 반응식
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:10]([O:12][CH3:13])=[O:11])[C@@H:3]([CH3:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6]>C(O)(=O)C.[Pd]>[NH2:1][C@H:2]([C:10]([O:12][CH3:13])=[O:11])[C@@H:3]([CH3:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6]

참가 물질

4

반응물 1

HCID 59113197Z-Thr(tbu)-ome

생성물 1

HCID 7018834(2S,3R)-Methyl 2-amino-3-(tert-butoxy)butanoate수율 96.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 176Acetic Acid용매

실험 절차

12.92 g (40 mmols) of Z-Thr(tBu)-OMe are hydrogenated in 200 ml of glacial acetic acid and 3 g of Pd on charcoal (10 %) at room temperature. The absorption of hydrogen is complete after 1 hour. The solution is freed of the catalyst by filtration and is evaporated under a waterpump vacuum at 35°C. After drying in a high vacuum at 35°C, 7.3 g of an oil result which according to a thin layer chromatogram is homogeneous and is directly used further.

후처리

  1. customat room temperature
  2. customThe absorption of hydrogen
  3. filtrationThe solution is freed of the catalyst by filtration
  4. customis evaporated under a waterpump vacuum at 35°C
  5. customAfter drying in a high vacuum at 35°C

출처 및 근거

ORD 기록
ord-69fd7e875c5648beb449ca80ca2b612a
출처 데이터셋
uspto-grants-1976_01
특허 번호
US03934008

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