3,4,5-Trimethoxybenzaldehyde → HCID 21853792, 화합물

HRID 1580938

반응식

HRID 1580938 반응식
C[O-].[Na+].[CH3:4][C:5]1[N:6]=[C:7]2[C:16]([CH3:17])=[CH:15][CH:14]=[CH:13][N:8]2[C:9](=[O:12])[C:10]=1[CH3:11].[CH3:18][O:19][C:20]1[CH:21]=[C:22]([CH:25]=[C:26]([O:30][CH3:31])[C:27]=1[O:28][CH3:29])[CH:23]=O>C(O)C>[CH3:11][C:10]1[C:9](=[O:12])[N:8]2[CH:13]=[CH:14][CH:15]=[C:16]([CH3:17])[C:7]2=[N:6][C:5]=1/[CH:4]=[CH:23]/[C:22]1[CH:25]=[C:26]([O:30][CH3:31])[C:27]([O:28][CH3:29])=[C:20]([O:19][CH3:18])[CH:21]=1

참가 물질

5

반응물 3

HCID 68583,4,5-TrimethoxybenzaldehydeHCID 10942334Sodium MethoxideHCID 123397192,3,9-Trimethyl-4H-pyrido[1,2-a]pyrimidin-4-one

생성물 1

HCID 21853792HCID 21853792, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 1.3g of sodium methoxide in 75ml of absolute ethanol is added 2.0g of 2,3,9-trimethyl-4H-pyrido-[1,2-a]pyrimidin-4-one, followed by 4.0g of 3,4,5-trimethoxybenzaldehyde. The mixture is stirred and heated under reflux for 89 hours. The reaction mixture is cooled, the solid is filtered, washed with 20ml of ether and 25ml of water, dried, and recrystallized from 75ml of acetonitrile to yield the title compound, melting point 218°-219°C dec.

후처리

  1. temperatureheated
  2. temperatureunder reflux for 89 hours
  3. temperatureThe reaction mixture is cooled
  4. filtrationthe solid is filtered
  5. washwashed with 20ml of ether and 25ml of water
  6. customdried
  7. customrecrystallized from 75ml of acetonitrile

출처 및 근거

ORD 기록
ord-d89cf70173b24f458c8421a5b15a938f
출처 데이터셋
uspto-grants-1976_01
특허 번호
US03935197

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