Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloroethyl isocyanate → GSK163090 (dihydrochloride)
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloroethyl isocyanate | HCID 16035 | — |
| 반응물 | Gsk163090 | HCID 11292933 | — |
| 반응물 | 3-(2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline | HCID 49852105 | — |
| 생성물 | GSK163090 (dihydrochloride) | HCID 49836021 | 22% |
반응 단계
The title compound was prepared in 22% yield according to the general procedure for the synthesis of cyclic ureas and carbamates (Method G) starting from 3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline (D3) and 1-chloro-2-isocyanatoethane, via the free base 1-(3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732600B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-233dfd8503c14677ae0bc39db5d7a21f |
| 출처 메모 | uspto-grants-2010_06 |