Ethyl 2-(4-methylphenylsulfonamido)acetate → Ethyl 2-(((2-Ethoxy-2-oxoethyl)((4-methylphenyl)sulfonyl)amino)methyl)-5-iodonicotinate

HRID 1581562노트

반응식

HRID 1581562 반응식
Br[CH2:2][C:3]1[N:13]=[CH:12][C:11]([I:14])=[CH:10][C:4]=1[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:15][C:16]1[CH:21]=[CH:20][C:19]([S:22]([NH:25][CH2:26][C:27]([O:29][CH2:30][CH3:31])=[O:28])(=[O:24])=[O:23])=[CH:18][CH:17]=1.[O-]CC.[Na+]>C(O)C>[CH2:30]([O:29][C:27](=[O:28])[CH2:26][N:25]([CH2:2][C:3]1[N:13]=[CH:12][C:11]([I:14])=[CH:10][C:4]=1[C:5]([O:7][CH2:8][CH3:9])=[O:6])[S:22]([C:19]1[CH:18]=[CH:17][C:16]([CH3:15])=[CH:21][CH:20]=1)(=[O:23])=[O:24])[CH3:31]

참가 물질

5

반응물 3

HCID 230685Ethyl 2-(4-methylphenylsulfonamido)acetateHCID 2723922Sodium ethoxideHCID 22722039Ethyl 2-(Bromomethyl)-5-iodonicotinate

생성물 1

HCID 22722035Ethyl 2-(((2-Ethoxy-2-oxoethyl)((4-methylphenyl)sulfonyl)amino)methyl)-5-iodonicotinate

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

Ethyl 2-(bromomethyl)-5-iodonicotinate (Preparation 10, 9.25 g) and ethyl (((4-methylphenyl)sulfonyl)amino)acetate (7.0 g) are dissolved in anhydrous ethanol (50 mL) and a solution of sodium ethoxide (3.4 g) in ethanol (45 mL) is added over 15 min. The mixture is stirred overnight and then poured into ice water. The mixture is extracted with ethyl acetate (3×100 mL) and the organic layer is concentrated.

후처리

  1. extractionThe mixture is extracted with ethyl acetate (3×100 mL)
  2. concentrationthe organic layer is concentrated

출처 및 근거

ORD 기록
ord-cc8685b670424486925ff0b9928943e4
출처 데이터셋
uspto-grants-2004_05
특허 번호
US06730682B2

반응 노트

불러오는 중…