Thiazolidinedione → 5-(4-Methoxybenzylidene)-thiazolidine-2,4-dione

HRID 1581648노트

반응식

HRID 1581648 반응식
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH:7]=O)=[CH:5][CH:4]=1.[S:11]1[CH2:15][C:14](=[O:16])[NH:13][C:12]1=[O:17].N1CCCCC1>C(O)C>[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH:7]=[C:15]2[S:11][C:12](=[O:17])[NH:13][C:14]2=[O:16])=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 5437ThiazolidinedioneHCID 8082PiperidineHCID 312444-Methoxybenzaldehyde

생성물 1

HCID 2331125-(4-Methoxybenzylidene)-thiazolidine-2,4-dione수율 32%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

4-Methoxybenzaldehyde (20.4 g, 150 mmol), thiazolidine-2,4-dione (21.1 g, 180 mmol), piperidine (12.8 g, 150 mmol) and ethanol (150 mL) were mixed and refluxed for 18 hours. After allowed to stand for cooling, the precipitated crystals were collected by filtration. These were washed with ethanol, and then dried to obtain 11.2 g (32%) of the title compound as yellow crystals. Moreover, the filtrate was made acidic with concentrated hydrochloric acid, and the precipitated crystals were collected by filtration, washed with ethanol and water, and then dried to additionally obtain 18.1 g (51%, totally 83%) of the title compound as yellow crystals.

후처리

  1. temperaturerefluxed for 18 hours
  2. temperaturefor cooling
  3. filtrationthe precipitated crystals were collected by filtration
  4. washThese were washed with ethanol
  5. customdried

출처 및 근거

ORD 기록
ord-6d75d2ea75dd479499a05eb2ed78447d
출처 데이터셋
uspto-grants-2004_05
특허 번호
US06730687B1

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