Tetrahydrofuran → HCID 11118078, 화합물

HRID 1581649노트

반응식

HRID 1581649 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]=[C:10]2[S:14][C:13](=[O:15])[NH:12][C:11]2=[O:16])=[CH:5][CH:4]=1.O1CCCC1>[Pd].C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH:10]2[S:14][C:13](=[O:15])[NH:12][C:11]2=[O:16])=[CH:7][CH:8]=1

참가 물질

5

반응물 2

HCID 8028TetrahydrofuranHCID 2331125-(4-Methoxybenzylidene)-thiazolidine-2,4-dione

생성물 1

HCID 11118078HCID 11118078, 화합물수율 97%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

5-[(4-Methoxyphenyl)methylidene]thiazolidine-2,4-dione (6.00 g, 25.5 mmol), 10% palladium on carbon (6.00 g) and a mixed solvent of tetrahydrofuran and ethanol (2:1 v/v, 300 mL) were mixed, and hydrogenation was performed at room temperature and at an initial pressure of 294 kPa. After completion of the reaction, catalyst was filtered and the filtrate was concentrated. The residue was purified by silica gel chromatography (eluate n-hexane: ethyl acetate=2:1 v/v) to obtain 5.84 g (97%) of the title compound as colorless powder.

후처리

  1. customwas performed at room temperature
  2. customAfter completion of the reaction, catalyst
  3. filtrationwas filtered
  4. concentrationthe filtrate was concentrated
  5. customThe residue was purified by silica gel chromatography (eluate n-hexane: ethyl acetate=2:1 v/v)

출처 및 근거

ORD 기록
ord-5061c0be22b4472e954f66723d78019f
출처 데이터셋
uspto-grants-2004_05
특허 번호
US06730687B1

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