Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Dichloroethane → N-Methyl-N-(1-methyl-1H-indazol-3-ylmethyl)-2-phenylbenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2-Dichloroethane | HCID 11 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | o-Phenylbenzoic acid | HCID 70357 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | N-Methyl-N-[(1-methyl-1H-indazol-3-yl)methyl]amine | HCID 7537473 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-Methyl-N-(1-methyl-1H-indazol-3-ylmethyl)-2-phenylbenzamide | HCID 9798740 | 62.2% |
반응 단계
A solution of 2-biphenylcarboxylic acid (198 mg, 1 mmole), 1-methyl-3-(methylaminomethyl)-1H-indazole (210 mg, 1.2 mmole), EDC (230 mg, 1.2 mmole), HOBt.H2O (162 mg, 1.2 mmole), and triethylamine (0.28 mL, 2.0 mmole) in DMF (5 mL) was stirred at RT. After 18 hr, the reaction was concentrated to dryness, and the residue was purified by flash chromatography on silica gel (45% EtOAc/hexanes). The title compound (221 mg, 62%) was obtained as a white solid: MS (ES) m/e 356 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06730684B1 |
| 출처 데이터셋 | uspto-grants-2004_05 |
| ORD ID | ord-9fd9e588799648d3bdebc4746bc4b3d8 |
| 출처 메모 | uspto-grants-2004_05 |