N-[2-(5-nitro-1H-indol-3-yl)ethyl]acetamide → N-[2-(5-Amino-1H-indol-3-yl)ethyl]acetamide
반응식
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH:8]=[C:7]2[CH2:13][CH2:14][NH:15][C:16](=[O:18])[CH3:17])([O-])=O>[Pd].C(O)C>[NH2:1][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH:8]=[C:7]2[CH2:13][CH2:14][NH:15][C:16](=[O:18])[CH3:17]참가 물질
4
실험 절차
The product from Example 2 (0.05 mmol) is taken into ethanol (3 mL) and hydrogenated 6 h at 3 atmospheres of H2 pressure over a catalytic amount of 10% Pd/C. The catalyst is removed by filtration through Celite and the solvent removed in vacuo, affording the title compound. This product is somewhat air sensitive and is used immediately for subsequent reactions.
후처리
- customThe catalyst is removed by filtration through Celite
- customthe solvent removed in vacuo
출처 및 근거
- ORD 기록
- ord-3d06ed28c8df4b51a5d3ea72070d9562
- 출처 데이터셋
- uspto-grants-2004_05
- 특허 번호
- US06730707B2
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