(R)-(-)-3-chloromethylsulfinyl-7-fluoro-1-methyl-4-quinolone → 3-Chloromethylthio-7-fluoro-1-methyl-4-quinolone

HRID 1581766

반응식

HRID 1581766 반응식
[Cl:1][CH2:2][S@:3]([C:5]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][C:10]([F:16])=[CH:11][CH:12]=2)[N:7]([CH3:17])[CH:6]=1)=O.ClC[S@@](C1C(=O)C2C(=CC(F)=CC=2)N(C)C=1)=O.FC1C=C2C(C(=S)C(C)=CN2C)=CC=1>>[Cl:1][CH2:2][S:3][C:5]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][C:10]([F:16])=[CH:11][CH:12]=2)[N:7]([CH3:17])[CH:6]=1

참가 물질

4

반응물 3

HCID 10445996(R)-(-)-3-chloromethylsulfinyl-7-fluoro-1-methyl-4-quinoloneHCID 10445997(S)-(+)-3-chloromethylsulfinyl-7-fluoro-1-methyl-4-quinoloneHCID 865891517-Fluoro-1-methyl-3-methylthio-4-quinolone

생성물 1

HCID 104452083-Chloromethylthio-7-fluoro-1-methyl-4-quinolone

실험 절차

FIG. 9 depicts the second step in the synthesis of e.e.(S)-(+)-3-chloromethylsulfinyl-7-fluoro-1-methyl-4-quinolone and (R)-(−)-3-chloromethylsulfinyl-7-fluoro-1-methyl-4-quinolone. In this step, 7-fluoro-1-methyl-3-methylthio-4-quinolone is chlorinated as described to produce 3-chloromethylthio-7-fluoro-1-methyl-4-quinolone.

후처리

  1. customin the synthesis of e.e

출처 및 근거

ORD 기록
ord-ba704b18a28a44fc8338f68904a66385
출처 데이터셋
uspto-grants-2004_05
특허 번호
US06730790B2

연결된 노트

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