BISOPROLOL FUMARATE → Bisoprolol

HRID 1581900노트

반응식

HRID 1581900 반응식
[CH3:1][CH:2]([NH:4][CH2:5][CH:6]([OH:23])[CH2:7][O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][O:16][CH2:17][CH2:18][O:19][CH:20]([CH3:22])[CH3:21])=[CH:13][CH:14]=1)[CH3:3].C(/C(O)=O)=C\C(O)=O>O>[CH3:3][CH:2]([NH:4][CH2:5][CH:6]([OH:23])[CH2:7][O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][O:16][CH2:17][CH2:18][O:19][CH:20]([CH3:22])[CH3:21])=[CH:13][CH:14]=1)[CH3:1]

참가 물질

3

반응물 1

HCID 6917733BISOPROLOL FUMARATE

생성물 1

HCID 2405Bisoprolol

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of bisoprolol was prepared as follows. To 529.2 g of purified water were added 180 g of bisoprolol fumarate 2:1. The mixture was stirred for 10 minutes to dissolve the drug. 10.8 g of talc USP (Whitaker, Clark and Daniels Inc., South Plainfield, N.J., USA) were added to the solution and the mixture was stirred for 20 minutes.

후처리

  1. dissolutionto dissolve the drug
  2. stirringthe mixture was stirred for 20 minutes

출처 및 근거

ORD 기록
ord-481f489f89154a1d87d9b2d300813349
출처 데이터셋
uspto-grants-2004_05
특허 번호
US06733789B1

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