Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cysteamine Hydrochloride → 7-Oxa-1-thia-4-azaspiro[4.4]nonane, 6-methyl-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cysteamine Hydrochloride | HCID 9082 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Dihydro-2-methyl-3(2H)-furanone | HCID 18522 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 7-Oxa-1-thia-4-azaspiro[4.4]nonane, 6-methyl- | HCID 12980245 | 90% |
반응 단계
To 15.4 g of 2-aminoethanethiol-HCl (0.13 mole) dissolved into 50 ml of water were added slowly 20 g of 2-methyl-3-tetrahydrofuranone (0.2 mole) (solution pH=2.7). The pH was kept to neutrality by adding 10% aqueous NaOH. After 1 hour, extraction of the water solution with Et2O, drying of the organic phase with MgSO4 and distillation of the crude product (Bp 1.7 mbar, 93°-96° C.) gave 18 g of the desired product (yield=90%). The product was obtained as a mixture of two diastereoisomers (isomers a and b).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06734158B2 |
| 출처 데이터셋 | uspto-grants-2004_05 |
| ORD ID | ord-875c204cc1be47828cd8cebd74113a17 |
| 출처 메모 | uspto-grants-2004_05 |