Trifluoroacetic acid → 2-(6-Methoxy-1,3,4,9-tetrahydro-beta-carboline-2-sulfonylmethyl)-3-methylbutyric acid

Trifluoroacetic acid (1 ml) was added to a solution of 2-(6-methoxy-1,3,4,9-tetrahydro-β-carboline-2-sulfonylmethyl)-3-methyl-butyric acid tert-butyl ester (237 mg) in dichloromethane (10 ml) at room temperature under nitrogen. The mixture was stirred for 2 h before being evaporated under reduced pressure. The residue was partitioned between 1M aqueous sodium hydroxide (15 ml) and diethyl ether (15 ml). The organics were extracted with 1M aqueous sodium hydroxide (15 ml). The combined aqueous portions were acidified to pH=5 with 10% citric acid and extracted with ethyl acetate (4×20 ml). The combined organics were washed with water (2×10 ml) and brine (10 ml), then dried (MgSO4), filtered and the solvent removed under reduced pressure to give, after chromatography (SiO2, 20:1 dichloromethane-methanol), the title compound (128 mg, 62%) as a white foam.

1. custombefore being evaporated under reduced pressure
2. customThe residue was partitioned between 1M aqueous sodium hydroxide (15 ml) and diethyl ether (15 ml)
3. extractionThe organics were extracted with 1M aqueous sodium hydroxide (15 ml)
4. extractionextracted with ethyl acetate (4×20 ml)
5. washThe combined organics were washed with water (2×10 ml) and brine (10 ml)
6. dry with materialdried (MgSO4)
7. filtrationfiltered
8. customthe solvent removed under reduced pressure
9. customto give

ORD 기록

ord-e6dcdd1abf2e40f1a7d64572afb839b3

출처 데이터셋

uspto-grants-2004_05

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US06734189B2