Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Glycine ethyl ester → N-Oleoylglycine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Glycine ethyl ester | HCID 12176 | — |
| 반응물 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 반응물 | Glycinamide | HCID 69020 | — |
| 반응물 | Oleic Acid | HCID 445639 | — |
| 반응물 | Oleoyl Sarcosine | HCID 6912870 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | N-Oleoylglycine | HCID 6436908 | — |
반응 단계
N-Oleoyl glycine (FIG. 7) was prepared by coupling glycine ethyl ester to oleic acid with EDCI (Cravatt et al. (1996) J. Am. Chem. Soc. 118, 580-590; Patterson et al. (1996) J. Am. Chem. Soc. 118, 5938-5945) followed by sequential transformation to the carboxylic acid (LiOH) and glycinamide (EDCI, NH4OH;). N-Oleoyl sarcosine was purchased (Pfaltz and Bauer) and converted to its ethyl ester by coupling with EtOH (DCC).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06734204B1 |
| 출처 데이터셋 | uspto-grants-2004_05 |
| ORD ID | ord-af81aa2227444438b9d1b833f7984589 |
| 출처 메모 | uspto-grants-2004_05 |