Dimethylamine → HCID 22282638, 화합물
반응식
Br[C:2]1[CH:11]=[C:10]([Br:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:13][NH:14][CH3:15]>O>[Br:12][C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=[C:2]([N:14]([CH3:15])[CH3:13])[CH:11]=1참가 물질
4
실험 절차
The product from (451a) (2.0 g, 7.0 mmol) was dissolved in 10 mL of 40% dimethylamine solution in H2O. The reaction mixture was allowed to stir overnight. The solution was diluted to 40 mL with H2O and it was extracted with EtOAc for three times. The combined organic layer was dried over MgSO4. After concentration, the residue was purified on silica gel column to provide 4-bromo-2-dimethylaminoquinoline (451b) (0.69 g, 40%). MS (AP+): 251 (M+1).
후처리
- extractionwas extracted with EtOAc for three times
- dry with materialThe combined organic layer was dried over MgSO4
- concentrationAfter concentration
- customthe residue was purified on silica gel column
출처 및 근거
- ORD 기록
- ord-d953b726c1114df48f7b3dd114e2fb1d
- 출처 데이터셋
- uspto-grants-2004_05
- 특허 번호
- US06740649B2
반응 노트
불러오는 중…