benzyl (2R)-pyrrolidine-2-carboxylate hydrochloride → HCID 178525082, 화합물

HRID 1583169노트

반응식

HRID 1583169 반응식
Cl.[CH2:2]([O:9][C:10](=[O:16])[C@H:11]1[CH2:15][CH2:14][CH2:13][NH:12]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[C@H:17]1([C:26]([OH:28])=O)[CH2:22][CH2:21][C@H:20]([C:23]([OH:25])=O)[CH2:19][CH2:18]1>CCOC(C)=O>[CH2:2]([O:9][C:10]([C@H:11]1[CH2:15][CH2:14][CH2:13][N:12]1[C:26]([C@H:17]1[CH2:18][CH2:19][C@H:20]([C:23]([N:12]2[CH2:13][CH2:14][CH2:15][C@@H:11]2[C:10]([O:9][CH2:2][C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)=[O:16])=[O:25])[CH2:21][CH2:22]1)=[O:28])=[O:16])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 22827650benzyl (2R)-pyrrolidine-2-carboxylate hydrochlorideHCID 178525731HCID 178525731, 화합물

생성물 1

HCID 178525082HCID 178525082, 화합물수율 76%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Using General Procedure A with 2.0 g (8.2 mmol) D-Proline benzyl ester hydrochloride and 700 mg (4.1 mmol) trans-cyclohexane-1,4-dicarboxylic acid afforded, after flash chromatography (EtOAc), 1.67 g (76%) of the title compound as a colorless oil. MS m/e (%): 547 (M+H+, 100).

후처리

  1. customafforded

출처 및 근거

ORD 기록
ord-4f6b754e00354474818e156450af7b9f
출처 데이터셋
uspto-grants-2004_05
특허 번호
US06740760B2

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