Sulfuryl chloride → 4-(2-Bromo-1,1,2-trifluoroethoxy)-2-chlorophenol
반응식
[Br:1][CH:2]([F:14])[C:3]([F:13])([F:12])[O:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1.S(Cl)([Cl:18])(=O)=O>C1(SC2C=CC=CC=2)C=CC=CC=1.C(O)(=O)C>[Cl:18][C:7]1[CH:6]=[C:5]([O:4][C:3]([F:12])([F:13])[CH:2]([Br:1])[F:14])[CH:10]=[CH:9][C:8]=1[OH:11]참가 물질
5
실험 절차
12.2 g of 4-(2-bromo-1,1,2-trifluoroethoxy)-phenol and 5 drops of diphenyl sulfide were dissolved in 30 ml of glacial acetic acid, and 6.1 g of sulfuryl chloride were added, a little at a time, at 25° C. After 3 hours at 25° C., the volatile components were removed, the residue was taken up with 300 ml of methylene chloride, and the solution was washed with 100 ml of 10% strength NaHCO3 solution and 100 ml of water, dried over Na2SO4 and distilled at 82° C./0.3 mbar. Yield: 12.6 g.