4-(3-Bromopropyl)pyridine → 4-(Pyridin-4-YL)butanenitrile

반응식

[N:1]1[CH:6]=[CH:5][CH:4]=[C:3](CCCC#N)[CH:2]=1.[N:12]1C=[CH:16][C:15](CCCBr)=[CH:14][CH:13]=1>>[N:1]1[CH:2]=[CH:3][C:4]([CH2:16][CH2:15][CH2:14][C:13]#[N:12])=[CH:5][CH:6]=1

참가 물질

반응물 2

HCID 127470564-(3-Bromopropyl)pyridine

HCID 135575244-(Pyridin-3-yl)butanenitrile

생성물 1

HCID 135575314-(Pyridin-4-YL)butanenitrile수율 51%

실험 절차

4-Pyridinebutanenitrile was prepared according to the procedure employed in the synthesis of 3-pyridinebutanenitrile. From 73.1 g of the hydrobromide salt of 3-(4-pyridyl)propyl bromide there was obtained 19.35 g (51%) of 4-pyridinebutanenitrile, bp 140°-141° C./2.0 mm.

후처리

custom4-Pyridinebutanenitrile was prepared

출처 및 근거

ORD 기록: ord-3d9c6b16619c4c32aaa22dcaaf800499
출처 데이터셋: uspto-grants-1985_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04551460

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