5-(3-Pyridinyl)pentanoic acid → 4-Pyridinepentanoic acid

반응식

N1C=CC=C(CCC[CH2:10][C:11]([OH:13])=[O:12])C=1.[N:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][CH2:22]Br)=[CH:16][CH:15]=1>>[N:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][CH2:22][CH2:10][C:11]([OH:13])=[O:12])=[CH:16][CH:15]=1

참가 물질

반응물 2

HCID 114807975-(3-Pyridinyl)pentanoic acid

HCID 127470564-(3-Bromopropyl)pyridine

생성물 1

HCID 111713164-Pyridinepentanoic acid수율 24%

실험 절차

4-Pyridinevaleric acid was prepared according to the procedure employed in the preparation of 3-pyridinevaleric acid. From 56.0 g of the hydrobromide salt of 3-(4-pyridyl)propyl bromide there was obtained 10.4 g (24%) of 4-pyridinevaleric acid, mp 195°-200° C. The analytical sample was obtained from isopropanol, mp 200°-201° C.

후처리

custom4-Pyridinevaleric acid was prepared

출처 및 근거

ORD 기록: ord-f927d708ab7940c5a7124efe567641b9
출처 데이터셋: uspto-grants-1985_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04551460

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