Potassium Iodide → 7-(Pyridin-3-YL)heptanenitrile

HRID 1583421노트

반응식

HRID 1583421 반응식
[C-:1]#[N:2].[K+].[I-].[K+].[N:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]Cl)[CH:7]=1>CN(C)C=O.O>[N:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:1]#[N:2])[CH:7]=1

참가 물질

6

반응물 3

HCID 4875Potassium IodideHCID 9032Potassium CyanideHCID 135575283-(6-Chlorohexyl)pyridine

생성물 1

HCID 137397387-(Pyridin-3-YL)heptanenitrile수율 84.2%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

반응 조건

온도
100 °C

실험 절차

A mixture of 4.0 g of potassium cyanide, 0.85 g of potassium iodide and 10.1 g of 6-(3-pyridyl)hexyl chloride in 100 ml of dimethylformamide was heated at 100° C. overnight. The reaction mixture was diluted with 200 ml of water and was extracted with dichloromethane. The combined organic layers were washed with water, dried over potassium carbonate and were evaporated. The residue was distilled to give 8.1 g (84%) of 3-pyridine heptanenitrile.

후처리

  1. extractionwas extracted with dichloromethane
  2. washThe combined organic layers were washed with water
  3. dry with materialdried over potassium carbonate
  4. customwere evaporated
  5. distillationThe residue was distilled

출처 및 근거

ORD 기록
ord-c3aa296857b643fd97ce27678c121ce5
출처 데이터셋
uspto-grants-1985_11
특허 번호
US04551460

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