Oxirane, [(2,3-dimethylphenoxy)methyl]- → HCID 13506762, 화합물

HRID 1583440노트

반응식

HRID 1583440 반응식
[CH3:1][O:2][C:3]([C:5]1[CH:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[CH3:21])[C:13]2[C:12](=[O:22])[CH2:11][NH:10][CH2:9][C:8]=2[NH:7][C:6]=1[CH3:23])=[O:4].[CH3:24][C:25]1[C:35]([CH3:36])=[CH:34][CH:33]=[CH:32][C:26]=1[O:27][CH2:28][CH:29]1[O:31][CH2:30]1>CO>[CH3:1][O:2][C:3]([C:5]1[CH:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[CH3:21])[C:13]2[C:12](=[O:22])[CH2:11][N:10]([CH2:30][CH:29]([OH:31])[CH2:28][O:27][C:26]3[CH:32]=[CH:33][CH:34]=[C:35]([CH3:36])[C:25]=3[CH3:24])[CH2:9][C:8]=2[NH:7][C:6]=1[CH3:23])=[O:4]

참가 물질

4

반응물 2

HCID 12619677Oxirane, [(2,3-dimethylphenoxy)methyl]-HCID 12818458HCID 12818458, 화합물

생성물 1

HCID 13506762HCID 13506762, 화합물수율 41.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1,4,5,6,7,8-Hexahydro-2-methyl-4-(2-methylphenyl)-5-oxo-1,7-naphthyridine-3-carboxylic acid methyl ester (14.5 g), 6.8 g of 3-(2,3-dimethylphenoxy)-1,2-epoxypropane and 250 ml of methanol were combined and refluxed for 18 hours. The solvent was removed in vacuo. The residue was dissolved in diethyl ether and saturated with hydrogen chloride. The solid was separated and dried in vacuo at 75° C. for 18 hours. The solid was recrystallized from acetonitrile to obtain 7.7 g of the title compound as the hydrochloride salt, m.p. 220° C. dec.

후처리

  1. temperaturerefluxed for 18 hours
  2. customThe solvent was removed in vacuo
  3. dissolutionThe residue was dissolved in diethyl ether and saturated with hydrogen chloride
  4. customThe solid was separated
  5. customdried in vacuo at 75° C. for 18 hours
  6. customThe solid was recrystallized from acetonitrile

출처 및 근거

ORD 기록
ord-220563bc64f346139d61676428fe3e7a
출처 데이터셋
uspto-grants-1985_11
특허 번호
US04551534

반응 노트

불러오는 중…