Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Iodoethane → (alphaS)-3-ethyl-3-(mercaptomethyl)-alpha-methyl-2-oxo-1-pyrrolidineacetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Iodoethane | HCID 6340 | — |
| 반응물 | Benzylthiobromomethane | HCID 4067177 | — |
| 반응물 | (S)-2-(2-oxopyrrolidin-1-yl)propanoic acid | HCID 7175678 | — |
| 생성물 | (alphaS)-3-ethyl-3-(mercaptomethyl)-alpha-methyl-2-oxo-1-pyrrolidineacetic acid | HCID 18600216 | — |
반응 단계
Following the procedures of Examples 1C-1E, α(S)-methyl-2-oxo-1-pyrrolidineacetic acid was first alkylated with ethyl iodide and then with benzylmercaptomethyl bromide. Removal of the benzyl group in the usual way and purification by chromatography provided the title compound as a mixture of diastereomers. [α]D25 =-4.04° (c=1, methanol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04552889 |
| 출처 데이터셋 | uspto-grants-1985_11 |
| ORD ID | ord-f5282b269af4496fb176721b5249d416 |
| 출처 메모 | uspto-grants-1985_11 |