Hydrogen Peroxide → 4-(2-Fluoroethoxy)phenol

HRID 1583586노트

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HRID 1583586 반응식
C[OH:2].S(=O)(=O)(O)O.[F:8][CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][C:15](C(C)=C)=[CH:14][CH:13]=1.OO>O>[F:8][CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([OH:2])=[CH:14][CH:13]=1

참가 물질

6

반응물 4

HCID 784Hydrogen PeroxideHCID 887MethanolHCID 1118Sulfuric AcidHCID 202592654-(2-Fluoroethoxy)isopropenylbenzene

생성물 1

HCID 150586584-(2-Fluoroethoxy)phenol

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
40 °C

실험 절차

Then, a mixture of 30 ml of methanol and 2 ml of concentrated sulfuric acid was warmed to 40° C., and 9.0 g of the resulting crude 4-(2-fluoroethoxy)-isopropenylbenzene prepared as above and a 30% aqueous solution of hydrogen peroxide were separately added dropwise to the warmed mixture over the course of 20 minutes. The reaction was continued for 1 hour. The reaction mixture was cooled, poured into water, and extracted with toluene. The toluene layer was washed with water, and dried over anhydrous sodium sulfate. Toluene was evaporated under reduced pressure to give 7.3 g of crude 4-(2-fluoroethoxy)phenol. The resulting crude phenol was recrystallized to give 6.8 g of pure 4-(2-fluoroethoxy)phenol as crystals.

후처리

  1. additionwere separately added dropwise to the warmed mixture over the course of 20 minutes
  2. temperatureThe reaction mixture was cooled
  3. extractionextracted with toluene
  4. washThe toluene layer was washed with water
  5. dry with materialdried over anhydrous sodium sulfate
  6. customToluene was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-1f55a6682b5147af894f6a56cda6064a
출처 데이터셋
uspto-grants-1985_11
특허 번호
US04552894

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