2-(2-Nitrophenyl)-3,1-benzoxazin-4-one → 2-(2-aminophenyl)-4H-3,1-benzoxazin-4-one

HRID 1583741노트

반응식

HRID 1583741 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[O:15][C:14](=[O:16])[C:13]2[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=2[N:11]=1)([O-])=O>C(OCC)(=O)C.[Pt]=O>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[O:15][C:14](=[O:16])[C:13]2[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=2[N:11]=1

참가 물질

4

반응물 1

HCID 3476752-(2-Nitrophenyl)-3,1-benzoxazin-4-one

생성물 1

HCID 8383952-(2-aminophenyl)-4H-3,1-benzoxazin-4-one

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 8857Ethyl Acetate용매

실험 절차

2-(2-Nitrophenyl)-3,1-benzoxazin-4-one (1.1 g, 4.10 mmole) was suspended in 40 ml of ethyl acetate, with platinum oxide (100 mg) being added, and the resulting reaction mixture was hydrogenated at atmospheric pressure with vigorous stirring. After 3 hours, the catalyst was removed and the solvent was rotoevaporated. The residual yellow oil was subjected to flash chromatography to give a homogeneous product. Recrystallization from acetone provided the analytical sample, m.p. 163°-165° C. (lit.* 162° C.).

후처리

  1. additionbeing added
  2. customthe resulting reaction mixture
  3. customthe catalyst was removed
  4. customto give a homogeneous product
  5. customRecrystallization from acetone
  6. customprovided the analytical sample, m.p. 163°-165° C. (lit.* 162° C.)

출처 및 근거

ORD 기록
ord-93673244aa4948aeafe61369154663f8
출처 데이터셋
uspto-grants-1985_11
특허 번호
US04554272

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