Sodium Hydroxide → 2-(2,4-Dimethoxyphenyl)ethan-1-amine

HRID 1583760

반응식

HRID 1583760 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[CH:11]=[CH:12][N+:13]([O-])=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>O1CCCC1.CCOCC>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[CH2:11][CH2:12][NH2:13]

참가 물질

6

반응물 3

HCID 14798Sodium HydroxideHCID 2754052,4-Dimethoxy-1-(2-nitroethenyl)benzeneHCID 21226445Aluminium lithium hydride

생성물 1

HCID 4176042-(2,4-Dimethoxyphenyl)ethan-1-amine

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매

실험 절차

The ethylene compound in 500 ml of tetrahydrofuran was added to 36.7 g of lithium aluminum hydride in 500 ml of ether. After a reflux period of 1.5 hours, the mixture was combined with 184 ml of lN sodium hydroxide solution. The resulting cake was separated by filtration and washed with 200 ml of hot tetrahydrofuran. The ethereal extracts and mother liquors were stripped. The residual oil was taken into chloroform, dried and stripped to give 94.9 g of 2,4-dimethoxyphenethylamine as an oil.

후처리

  1. customThe resulting cake was separated by filtration
  2. washwashed with 200 ml of hot tetrahydrofuran
  3. customdried

출처 및 근거

ORD 기록
ord-806561b4111e483198c47d83a09b1c06
출처 데이터셋
uspto-grants-1985_11
특허 번호
US04554284

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