Ethanol → HCID 20198008, 화합물
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[CH3:1][C:2]1([CH3:11])[C:4]2([CH2:9][CH2:8][C:7]([CH3:10])=[CH:6][CH2:5]2)[O:3]1.C1(C)C=CC(S(O)(=O)=O)=CC=1.[CH2:23]([OH:25])[CH3:24]>>[CH2:23]([O:25][C:2]([C:4]1([OH:3])[CH2:9][CH2:8][C:7]([CH3:10])=[CH:6][CH2:5]1)([CH3:11])[CH3:1])[CH3:24]참가 물질
4
실험 절차
By procedures similar to those described in Embodiments 57 and 58, 2,2,6-trimethyl-1-oxaspiro(2.5)oct-5-ene was treated with ethanol in the presence of p-toluenesulfonic acid to obtain 1-(1-ethoxy-1-methyl-ethyl)-4-methyl-3-cyclohexen-ol. This alcohol was treated with vanadium(IV) bis(2,4-pentanedionate) oxide and tert-butyl hydroperoxide followed by p-toluenesulfonic acid to obtain (±)-2-exo-hydroxy-4(1-ethoxy-1-methylethyl)-1methyl-7-oxabicyclo [2.2.1]heptane. This intermediate was treated with benzyl chloride to yield the desired product, b.p. 120°-125° C. (0.2 mm).
출처 및 근거
- ORD 기록
- ord-79aeb2ccade749659ff7d7118339d800
- 출처 데이터셋
- uspto-grants-1985_11
- 특허 번호
- US04554366
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