1-Bromohexadecane → HCID 13076757, 화합물

HRID 1583919노트

반응식

HRID 1583919 반응식
[C:1]([C:5]1[C:14]([OH:15])=[CH:13][C:8]2[N:9]=[C:10]([CH3:12])[O:11][C:7]=2[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+].[CH2:22](Br)[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37]>CN(C)C=O>[C:1]([C:5]1[C:14]([O:15][CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH3:22])=[CH:13][C:8]2[N:9]=[C:10]([CH3:12])[O:11][C:7]=2[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

5

반응물 3

HCID 82131-BromohexadecaneHCID 11430Potassium CarbonateHCID 12886750HCID 12886750, 화합물

생성물 1

HCID 13076757HCID 13076757, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

6.9 g of the benzoxazole derivative obtained in Step (c) above was dissolved in 50 ml of dimethylformamide and the solution was stirred at 80° to 90° C. for 6 hours together with 8 g of anhydrous potassium carbonate and 11 g of hexadecyl bromide. After the completion of the reaction, the insoluble material was removed by filtration. To the filtrate was added 150 ml of methanol and the mixture was cooled with ice to precipitate crystals. The crystals were collected by filtration, thus obtained 8.8 g (62%) yield) of 6-tert-butyl-5-hexadecyloxy-2-methylbenzoxazole.

후처리

  1. customAfter the completion of the reaction
  2. customthe insoluble material was removed by filtration
  3. additionTo the filtrate was added 150 ml of methanol
  4. temperaturethe mixture was cooled with ice
  5. customto precipitate crystals
  6. filtrationThe crystals were collected by filtration, thus obtained 8.8 g (62%)

출처 및 근거

ORD 기록
ord-de0d5940eb88473c8abcbf0953c28cc7
출처 데이터셋
uspto-grants-1985_11
특허 번호
US04555470

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