1,1'-Carbonyldiimidazole → 6-Chloro-N-[3-(2,4-dimethyl-1H-imidazol-1-yl)propyl]-3-pyridinecarboxamide

HRID 1583994노트

반응식

HRID 1583994 반응식
[CH3:1][C:2]1[N:3]([CH2:8][CH2:9][CH2:10][NH2:11])[CH:4]=[C:5]([CH3:7])[N:6]=1.[Cl:12][C:13]1[CH:21]=[CH:20][C:16]([C:17](O)=[O:18])=[CH:15][N:14]=1.C(N1C=CN=C1)(N1C=CN=C1)=O>>[Cl:12][C:13]1[N:14]=[CH:15][C:16]([C:17]([NH:11][CH2:10][CH2:9][CH2:8][N:3]2[CH:4]=[C:5]([CH3:7])[N:6]=[C:2]2[CH3:1])=[O:18])=[CH:20][CH:21]=1

참가 물질

4

반응물 3

HCID 682631,1'-CarbonyldiimidazoleHCID 792226-Chloronicotinic acidHCID 135889102,4-dimethyl-1H-imidazole-1-propanamine

생성물 1

HCID 202575956-Chloro-N-[3-(2,4-dimethyl-1H-imidazol-1-yl)propyl]-3-pyridinecarboxamide

실험 절차

When 2,4-dimethyl-1H-imidazole-1-propanamine is treated with a mixture of 6-chloronicotinic acid and 1,1'-carbonyldiimidazole by the procedure of Example 30 the compound of the Example is obtained.

후처리

  1. customis obtained

출처 및 근거

ORD 기록
ord-b38e082679284f15be954575a558a982
출처 데이터셋
uspto-grants-1985_11
특허 번호
US04555519

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