Acetonitrile → 2-Methylquinazoline

반응식

[NH2:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4](C1C=CC=CC=1)=O.[C:16](#[N:18])[CH3:17]>>[CH3:17][C:16]1[N:18]=[CH:4][C:3]2[C:2](=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:1]=1

참가 물질

반응물 2

HCID 6342Acetonitrile

HCID 760802-Aminobenzophenone

생성물 1

HCID 5889872-Methylquinazoline

실험 절차

In this method, 2-aminobenzophenone derivative (IV) is reacted with acetonitrile to yield 2-methylquinazoline derivative (IX), which is then brominated to 2-bromomethylquinazoline derivative (II-4). The reaction of compound (IV) and acetonitrile is carried out in the same manner as method D. Bromination of compound (IX) is carried out in the same manner as the bromination of compound (VII) by method C.

출처 및 근거

ORD 기록: ord-2154f7d610e34b06b569829eff29d7de
출처 데이터셋: uspto-grants-1999_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05932592

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