N-(tert-butoxy)-2-[1-(4-phenoxyphenylthio)cyclopent-1-yl]-acetamide → N-hydroxy-2-[1-(4-phenoxyphenylthio)-cyclopent-1-yl]-acetamide

HRID 1584397노트

반응식

HRID 1584397 반응식
C([O:5][NH:6][C:7](=[O:28])[CH2:8][C:9]1([S:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:17][CH:16]=2)[CH2:13][CH2:12][CH2:11][CH2:10]1)(C)(C)C>FC(F)(F)C(O)=O>[OH:5][NH:6][C:7](=[O:28])[CH2:8][C:9]1([S:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)=[CH:17][CH:16]=2)[CH2:13][CH2:12][CH2:11][CH2:10]1

참가 물질

3

반응물 1

HCID 21224113N-(tert-butoxy)-2-[1-(4-phenoxyphenylthio)cyclopent-1-yl]-acetamide

생성물 1

HCID 21224318N-hydroxy-2-[1-(4-phenoxyphenylthio)-cyclopent-1-yl]-acetamide

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

The N-tert-butoxy-2-[1-(4-phenoxyphenylthio)-cyclopent-1-yl]-acetamide was dissolved in trifluoroacetic acid (6 ml) and allowed to stand for 24 hours. The acid was evaporated off under reduced pressure and the product purified by preparative TLC, eluting with 6.5% methanol/methylene chloride gave N-hydroxy-2-[1-(4-phenoxyphenylthio)-cyclopent-1-yl]-acetamide (100 mg).

후처리

  1. customThe acid was evaporated off under reduced pressure
  2. customthe product purified by preparative TLC
  3. washeluting with 6.5% methanol/methylene chloride

출처 및 근거

ORD 기록
ord-ff650d42c7dc4b5b89dc19df337cac31
출처 데이터셋
uspto-grants-1999_08
특허 번호
US05932595

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