Chlorotrimethylsilane → Methyl 2-(3-nitrophenyl)acetate

HRID 15844

반응식

HRID 15844 반응식
[CH3:1][Si](Cl)(C)C.[N+:6]([C:9]1[CH:10]=[C:11]([CH2:15][C:16]([OH:18])=[O:17])[CH:12]=[CH:13][CH:14]=1)([O-:8])=[O:7]>CO>[N+:6]([C:9]1[CH:10]=[C:11]([CH2:15][C:16]([O:18][CH3:1])=[O:17])[CH:12]=[CH:13][CH:14]=1)([O-:8])=[O:7]

참가 물질

4

반응물 2

HCID 6397ChlorotrimethylsilaneHCID 158763-Nitrophenylacetic acid

생성물 1

HCID 526967Methyl 2-(3-nitrophenyl)acetate수율 100%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Trimethylsilyl chloride (5.6 mL, 2.0 equiv.) was added to a stirred solution of (3-nitrophenyl)acetic acid (4.0 g) in methanol (60 ml). The resulting solution was stirred at room temperature for 18 hours, then concentrated at reduced pressure and partitioned between DCM and aqueous sodium hydrogencarbonate solution. The organic phase was dried over sodium sulfate, filtered and concentrated under vacuum to give the title compound as a colourless liquid (4.2 g, 100%).

후처리

  1. concentrationconcentrated at reduced pressure
  2. custompartitioned between DCM and aqueous sodium hydrogencarbonate solution
  3. dry with materialThe organic phase was dried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-abfb52f871d248ef81b0d73cfbd63c99
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732600B2

연결된 노트

불러오는 중…