Isopropanol → 4-(1-(2-(fur-2-ylmethoxy)ethyl)-1H-benzimidazol-2-yl)[1,4]diazepane

HRID 1584454노트

반응식

HRID 1584454 반응식
C(OC([N:6]1[CH2:12][CH2:11][CH2:10][N:9]([C:13]2[N:17]([CH2:18][CH2:19][O:20][CH2:21][C:22]3[O:23][CH:24]=[CH:25][CH:26]=3)[C:16]3[CH:27]=[CH:28][CH:29]=[CH:30][C:15]=3[N:14]=2)[CH2:8][CH2:7]1)=O)C.[OH-].[K+].C(O)(C)C>O>[O:23]1[CH:24]=[CH:25][CH:26]=[C:22]1[CH2:21][O:20][CH2:19][CH2:18][N:17]1[C:16]2[CH:27]=[CH:28][CH:29]=[CH:30][C:15]=2[N:14]=[C:13]1[N:9]1[CH2:10][CH2:11][CH2:12][NH:6][CH2:7][CH2:8]1

참가 물질

5

반응물 3

HCID 3776IsopropanolHCID 14797Potassium HydroxideHCID 212236281-ethoxycarbonyl-4-(1-(2-(fur-2-ylmethoxy)ethyl)-1H-benzimidazol-2-yl)[1,4]diazepane

생성물 1

HCID 212235564-(1-(2-(fur-2-ylmethoxy)ethyl)-1H-benzimidazol-2-yl)[1,4]diazepane

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Combine 1-ethoxycarbonyl-4-(1-(2-(fur-2-ylmethoxy)ethyl)-1H-benzimidazol-2-yl)[1,4]diazepane (1 mmol), potassium hydroxide (1.2 mmol), and isopropanol (20 mL). Heat to reflux. After 18 hours, evaporate in vacuo to give a residue. Combine the residue and water. Extract with dichloromethane. Dry the organic layer over MgSO4, filter, and evaporate in vacuo to give the title compound.

후처리

  1. temperatureHeat to reflux
  2. customevaporate in vacuo
  3. customto give a residue
  4. extractionExtract with dichloromethane
  5. dry with materialDry the organic layer over MgSO4
  6. filtrationfilter
  7. customevaporate in vacuo

출처 및 근거

ORD 기록
ord-d9847c63aa724956a7f5554a0e347ac1
출처 데이터셋
uspto-grants-1999_08
특허 번호
US05932571

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