Potassium Carbonate → Methyl 2-methoxyimino-2-[3-chloro-2-(2-isopropoxy-6-trifluoromethylpyrimidin-4-yloxymethyl)phenyl]acetate

참여 물질

반응 단계

3.3 g of 2-isopropoxy-4-hydroxy-6-trifluoromethylpyrimidine and 2.4 g of potassium carbonate are stirred at room temperature (about 25° C.) for 30 min in 100 ml of dimethyl formamide and the mixture is then treated dropwise in the course of 1 hour with a solution of 4.8 g of methyl 2-methoxyimino-2-[2-bromomethyl-3-chlorophenyl]acetate in 30 ml of dimethylformamide. After a further 8 hours at room temperature, the reaction mixture is added to ice water and the product is extracted using tert-butyl methyl ether. The combined ether phases are dried and concentrated. The crude product thus obtained is purified by chromatography (silica gel/toluene). 4.2 g of the title compound are obtained.

출처 및 근거