Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Oxalyl chloride → 2-Chloro-4-methylpyrimidine-5-carbonyl chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 반응물 | 2-Chloro-4-methylpyrimidine-5-carboxylic acid | HCID 10487414 | — |
| 촉매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Chloro-4-methylpyrimidine-5-carbonyl chloride | HCID 21220650 | 61.3% |
반응 단계
A solution of 2-chloro-4-methylpyrimidine-5-carboxylic acid (0.81 g, 4.70 mmol), oxalyl chloride (0.89 g, 7.05 mmol), DMF (2 drops) in CH2Cl2 (23 mL) was stirred at room temperature under N2 for 4 h. The solution was concentrated and distilled to give the title compound (0.55 g, 61%); b.p. 90-100° C., 1.3 mm/Hg; 1H NMR (CDCl3) δ d9.02 (s, 1H), 2.74 (s, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05935966 |
| 출처 데이터셋 | uspto-grants-1999_08 |
| ORD ID | ord-d375475290144e0fa6610171f81d8166 |
| 출처 메모 | uspto-grants-1999_08 |