Dimethyl-1,3-thiazole-5-carboxylic acid → HCID 57478356, 화합물

HRID 15850

반응식

HRID 15850 반응식
[CH3:1][CH:2]([C:21]1[CH:22]=[C:23]([CH:25]=[CH:26][CH:27]=1)[NH2:24])[CH2:3][N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:19]=[CH:18][CH:17]=[C:16]3[C:11]=2[CH:12]=[CH:13][C:14]([CH3:20])=[N:15]3)[CH2:6][CH2:5]1.[CH3:28][C:29]1[S:30][C:31]([C:35](O)=[O:36])=[C:32]([CH3:34])[N:33]=1>>[CH3:28][C:29]1[S:30][C:31]([C:35]([NH:24][C:23]2[CH:25]=[CH:26][CH:27]=[C:21]([CH:2]([CH3:1])[CH2:3][N:4]3[CH2:5][CH2:6][N:7]([C:10]4[CH:19]=[CH:18][CH:17]=[C:16]5[C:11]=4[CH:12]=[CH:13][C:14]([CH3:20])=[N:15]5)[CH2:8][CH2:9]3)[CH:22]=2)=[O:36])=[C:32]([CH3:34])[N:33]=1

참가 물질

3

반응물 2

HCID 736488Dimethyl-1,3-thiazole-5-carboxylic acidHCID 574443353-{1-Methyl-2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline

생성물 1

HCID 57478356HCID 57478356, 화합물수율 87%

실험 절차

The title compound was prepared in 87% yield according to the general procedure for the preparation of amides (Method C) starting from 3-{1-methyl-2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline (D21) and 2,4-dimethyl-1,3-thiazole-5-carboxylic acid.

출처 및 근거

ORD 기록
ord-5764fb485590493b92ea7889bc80ad77
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732600B2

연결된 노트

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