Methylamine → 1-(6-Fluoropyridin-3-yl)-N-methylmethanamine

HRID 1585018노트

반응식

HRID 1585018 반응식
[CH3:1][NH2:2].[F:3][C:4]1[N:9]=[CH:8][C:7]([CH2:10]Br)=[CH:6][CH:5]=1>CC#N>[F:3][C:4]1[N:9]=[CH:8][C:7]([CH2:10][NH:2][CH3:1])=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 220506385-(Bromomethyl)-2-fluoropyridine

생성물 1

HCID 224503141-(6-Fluoropyridin-3-yl)-N-methylmethanamine수율 61%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a mixture of 2.5 g of 40% aqueous methylamine solution and 30 ml of CH3CN was added dropwise 3.0 g of crude (6-fluoro-3-pyridyl)methyl bromide with constant stirring. The mixture was allowed to stand at room temperature overnight and concentrated under reduced pressure. The residue was extracted with AcOEt and the extract was dried over MgSO4 and concentrated. The procedure gave 1.35 g of the title compound as a crude orange-colored oil.

후처리

  1. concentrationconcentrated under reduced pressure
  2. extractionThe residue was extracted with AcOEt
  3. dry with materialthe extract was dried over MgSO4
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-058e785b2242402ca630f02db8227006
출처 데이터셋
uspto-grants-1999_08
특허 번호
US05935981

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