1-Benzyl-3-methyl-1-(pyridin-3-ylmethyl)thiourea → 1-(6-Chloro-3-pyridylmethyl)amino-1-dimethylamino-2-nitroethylene
반응식
[CH3:1][N:2]([CH3:10])[C:3](SC)=[CH:4][N+:5]([O-:7])=[O:6].C([N:18]([CH2:23][C:24]1[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=1)C(NC)=S)C1C=CC=CC=1.[Cl:30]C1N=CC(NC)=CC=1>>[Cl:30][C:27]1[N:26]=[CH:25][C:24]([CH2:23][NH:18][C:3]([N:2]([CH3:10])[CH3:1])=[CH:4][N+:5]([O-:7])=[O:6])=[CH:29][CH:28]=1참가 물질
4
실험 절차
The 1-dimethylamino-1-methylthio-2-nitroethylene (1.0 g) prepared in (1) and 1.0 g of 6-chloro-3-pyridyl- methylamine were refluxed in 30 ml of EtoH for 2 hours. The EtOH was then distilled off and the residue was subjected to silica gel column chromatography using CHCl3 -MeOH (10:1) as an eluent. The crystals obtained were recrystallized from EtOH to recover 0.82 g of the title compound as pale yellow crystals.