Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isethionic Acid → 2-[5-(2,6-Dimethoxyphenyl)-1-[4-[N-methyl-N-(3-dimethylaminopropyl)carbamoyl]-2-isopropylphenyl]-3-pyrazolylcarbonylamino]-2-adamantanecarboxylic acid isethionate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isethionic Acid | HCID 7866 | — |
| 반응물 | SR142948A | HCID 5311451 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 2-[5-(2,6-Dimethoxyphenyl)-1-[4-[N-methyl-N-(3-dimethylaminopropyl)carbamoyl]-2-isopropylphenyl]-3-pyrazolylcarbonylamino]-2-adamantanecarboxylic acid isethionate | HCID 86754287 | 46.5% |
반응 단계
A mixture of 0.1 g of the compound obtained in EXAMPLE 1' in 3 ml of 2-propanol is heated to reflux, 0.022 g of 83% isethionic acid (obtained by elution of sodium isethionate on DOWEX® 50W×8 resin in H+ form) is added and crystallization is allowed to take place overnight. The crystallized product formed is drained. 0.055 g of the expected product is obtained, m.p.=230° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05936123 |
| 출처 데이터셋 | uspto-grants-1999_08 |
| ORD ID | ord-8eb86bc0658845788bf6fb1a8f6caf89 |
| 출처 메모 | uspto-grants-1999_08 |