Hydrogen Peroxide → 1-Benzoyl-1,2-dihydroquinoline-2-carboxamide

HRID 1585568노트

반응식

HRID 1585568 반응식
[C:1]([N:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[CH:11][CH:10]1[C:19]#[N:20])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)(O)[O-:22].[Na+].OO>CC(C)=O>[C:1]([N:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[CH:11][CH:10]1[C:19]([NH2:20])=[O:22])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 784Hydrogen PeroxideHCID 262192-Quinolinecarbonitrile, 1,2-dihydro-1-benzoyl-HCID 516892Sodium Bicarbonate

생성물 1

HCID 2304901-Benzoyl-1,2-dihydroquinoline-2-carboxamide수율 55%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

1-(Benzoyl)-1,2-dihydro-quinoline-2-carbonitrile (26.0 g) was dissolved in acetone (500 mL). Solid sodium bicarbonate (15 g) was added. The mixture was stirred for 30 minutes. 30% Hydrogen peroxide solution (250 mL of a 30% solution) was added drop-wise. After stirring for 4 hours, the acetone was evaporated under vacuum. The residue was acidified with 1N HCl. The precipitate was collected, washed with water and air dried. The solid was slurried in ether then filtered. The title compound (15.3 g) was obtained as an off-white solid, m.p. 169-171° C.

후처리

  1. stirringAfter stirring for 4 hours
  2. customthe acetone was evaporated under vacuum
  3. customThe precipitate was collected
  4. washwashed with water and air
  5. customdried
  6. filtrationthen filtered

출처 및 근거

ORD 기록
ord-8a21f88e4da84c838575a2c8ae2a96a0
출처 데이터셋
uspto-grants-1999_08
특허 번호
US05939435

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