Methanol → 2-(2-Acetoxyethyl)thio-2',4'-difluoroacetophenone

HRID 1585659

반응식

Cl[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=1[F:12])=[O:4].[C:13]([O:16][CH2:17][CH2:18][SH:19])(=[O:15])[CH3:14].C(=O)([O-])[O-].[K+].[K+].CO>>[C:13]([O:16][CH2:17][CH2:18][S:19][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=1[F:12])=[O:4])(=[O:15])[CH3:14]

참가 물질

반응물 4

HCID 887Methanol

HCID 11430Potassium Carbonate

HCID 98505Ethanol, 2-mercapto-, 1-acetate

HCID 5880832-Chloro-1-(2,4-difluorophenyl)ethanone

생성물 1

HCID 106599152-(2-Acetoxyethyl)thio-2',4'-difluoroacetophenone수율 65.6%

실험 절차

Using 2-chloro-2',4'-difluoroacetophenone (2.0 g, 0.010 mol), 2-acetoxyethanethiol (J. Chem. Soc., 1952, 817.) (1.5 g, 0.013 mol), potassium carbonate (1.8 g, 0.013 mol) and methanol (50 mol), 2-(2-acetoxyethyl)thio-2',4'-difluoroacetophenone (1.8 g, yield: 62.0%) was obtained as a colorless oil by similar procedures to Example 1.

출처 및 근거

ORD 기록: ord-6fe9de6b2231489681d659d2fc16d7a0
출처 데이터셋: uspto-grants-1999_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05939448

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