HCID 21696991, 화합물 → HCID 9823286, 화합물

HRID 1585904노트

반응식

HRID 1585904 반응식
[OH:1][C:2]1[CH:9]=[C:8]([CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].Br[CH2:17][C:18]1[CH:19]=[CH:20][C:21]([N:24]2[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:25]2=[O:31])=[N:22][CH:23]=1>CN(C=O)C>[Cl:30][C:28]1[CH:27]=[CH:26][C:25](=[O:31])[N:24]([C:21]2[CH:20]=[CH:19][C:18]([CH2:17][O:1][C:2]3[CH:9]=[C:8]([CH2:10][N:11]4[CH:15]=[CH:14][N:13]=[CH:12]4)[CH:7]=[CH:6][C:3]=3[C:4]#[N:5])=[CH:23][N:22]=2)[CH:29]=1

참가 물질

4

반응물 2

HCID 21696991HCID 21696991, 화합물HCID 216970282-Hydroxy-4-imidazol-1-ylmethyl-benzonitrile

생성물 1

HCID 9823286HCID 9823286, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2-Hydroxy 4-imidazol-1-ylmethyl-benzonitrile (0.050 g, 0.25 mmol) and 5'-bromomethyl-5-chloro-[1,2']bipyridinyl-2-one (Example 10 Step 2) (0.079 g, 0.262 mmol) were dissolved in dry DMF (5 mL), treated with CsCO3 (0.123 g, 0.376 mmol) and stirred at ambient temperature for 18 hr. The reaction mixture was partitioned between EtOAc and aqueous satd NaHCO3 solution, the organic layer washed with H2O, brine, and dried (MgSO4). Chromatography (SiO2, 1-4% CH3OH in CH2Cl2) gave the title compound.

후처리

  1. customThe reaction mixture was partitioned between EtOAc and aqueous satd NaHCO3 solution
  2. washthe organic layer washed with H2O, brine
  3. dry with materialdried (MgSO4)

출처 및 근거

ORD 기록
ord-03e0eeb813ac4be2a869433f1a6d05e4
출처 데이터셋
uspto-grants-1999_08
특허 번호
US05939439

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