Diethyl [(2-bromophenyl)methylidene]propanedioate → Ethyl 3-(2-bromophenyl)-2-ethoxycarbonyl-3-methylpropionate

HRID 1585968

반응식

HRID 1585968 반응식
[CH2:1]([O:3][C:4]([C:6](=[CH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[Br:19])[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5])[CH3:2].[CH3:20][Mg]Br>CCOCC.[Cl-].[NH4+].[Cu](Br)Br>[Br:19][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[CH:12]([CH3:20])[CH:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[C:4]([O:3][CH2:1][CH3:2])=[O:5]

참가 물질

6

반응물 2

HCID 246693Diethyl [(2-bromophenyl)methylidene]propanedioateHCID 178418573HCID 178418573, 화합물

생성물 1

HCID 21217382Ethyl 3-(2-bromophenyl)-2-ethoxycarbonyl-3-methylpropionate

시약·촉매·용매 3

HCID 24611Copper bromide (CuBr2)촉매HCID 3283Diethyl Ether용매HCID 25517Ammonium Chloride용매

실험 절차

To a solution in 500 ml of ether of 50.98 g of ethyl α-ethoxycarbonyl-o-bromo-cinnamate (170.5 mmole) and 1.0 g of copper bromide was added dropwise 56.7 ml of an ethereal solution of methylmagnesium bromide (175.6 mmole) at -20° C. The mixture was stirred overnight at room temperature, diluted with an aqueous ammonium chloride solution to separate the phases. The organic phase was dried over magnesium sulfate and concentrated under reduced pressure to give ethyl 3-(2-bromophenyl)-2-ethoxycarbonyl-3-methylpropionate.

후처리

  1. customto separate the phases
  2. dry with materialThe organic phase was dried over magnesium sulfate
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-609869689b8d4703b7edca5bf824b63f
출처 데이터셋
uspto-grants-1999_08
특허 번호
US05942459

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